ADVERSE CHILDHOOD EXPERIENCES AND PRESCRIPTION STIMULANT USE IN ADULTS: A SYSTEMATIC REVIEW

Nonmedical prescription stimulant use (NPSU) is an ongoing public health crisis in the United States.There exists, however, a dearth of research investigating specific childhood risk factors that may contribute to this illicit use.Adverse childhood experiences (ACEs) may be a significant risk factor to address in the prevention and treatment of NPS

Accumulation of DNA damage leading to stem cell exhaustion has been proposed to be a principal mechanism of aging.Using 53BP1-foci Nattokinase as a marker for DNA double-strand breaks (DSBs), hair follicle stem cells (HFSCs) in mouse epidermis were analyzed for age-related DNA damage response (DDR).We observed increasing amounts of 53BP1-foci durin